Ontology highlight
ABSTRACT:
SUBMITTER: Simula L
PROVIDER: S-EPMC6302735 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Simula Luca L Pacella Ilenia I Colamatteo Alessandra A Procaccini Claudio C Cancila Valeria V Bordi Matteo M Tregnago Claudia C Corrado Mauro M Pigazzi Martina M Barnaba Vincenzo V Tripodo Claudio C Matarese Giuseppe G Piconese Silvia S Campello Silvia S
Cell reports 20181201 11
Mitochondria are key players in the regulation of T cell biology by dynamically responding to cell needs, but how these dynamics integrate in T cells is still poorly understood. We show here that the mitochondrial pro-fission protein Drp1 fosters migration and expansion of developing thymocytes both in vitro and in vivo. In addition, we find that Drp1 sustains in vitro clonal expansion and cMyc-dependent metabolic reprogramming upon activation, also regulating effector T cell numbers in vivo. Mi ...[more]