Identification of genes required for eye development by high-throughput screening of mouse knockouts.
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ABSTRACT:
SUBMITTER: Moore BA
PROVIDER: S-EPMC6303268 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Publications
Identification of genes required for eye development by high-throughput screening of mouse knockouts.
Moore Bret A BA Leonard Brian C BC Sebbag Lionel L Edwards Sydney G SG Cooper Ann A Imai Denise M DM Straiton Ewan E Santos Luis L Reilly Christopher C Griffey Stephen M SM Bower Lynette L Clary David D Mason Jeremy J Roux Michel J MJ Meziane Hamid H Herault Yann Y McKerlie Colin C Flenniken Ann M AM Nutter Lauryl M J LMJ Berberovic Zorana Z Owen Celeste C Newbigging Susan S Adissu Hibret H Eskandarian Mohammed M Hsu Chih-Wei CW Kalaga Sowmya S Udensi Uchechukwu U Asomugha Chinwe C Bohat Ritu R Gallegos Juan J JJ Seavitt John R JR Heaney Jason D JD Beaudet Arthur L AL Dickinson Mary E ME Justice Monica J MJ Philip Vivek V Kumar Vivek V Svenson Karen L KL Braun Robert E RE Wells Sara S Cater Heather H Stewart Michelle M Clementson-Mobbs Sharon S Joynson Russell R Gao Xiang X Suzuki Tomohiro T Wakana Shigeharu S Smedley Damian D Seong J K JK Tocchini-Valentini Glauco G Moore Mark M Fletcher Colin C Karp Natasha N Ramirez-Solis Ramiro R White Jacqueline K JK de Angelis Martin Hrabe MH Wurst Wolfgang W Thomasy Sara M SM Flicek Paul P Parkinson Helen H Brown Steve D M SDM Meehan Terrence F TF Nishina Patsy M PM Murray Stephen A SA Krebs Mark P MP Mallon Ann-Marie AM Lloyd K C Kent KCK Murphy Christopher J CJ Moshiri Ala A
Communications biology 20181221
Despite advances in next generation sequencing technologies, determining the genetic basis of ocular disease remains a major challenge due to the limited access and prohibitive cost of human forward genetics. Thus, less than 4,000 genes currently have available phenotype information for any organ system. Here we report the ophthalmic findings from the International Mouse Phenotyping Consortium, a large-scale functional genetic screen with the goal of generating and phenotyping a null mutant for ...[more]
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