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Intraoperative hyponatremia is an independent predictor of one-year mortality after liver transplantation.

ABSTRACT: Preoperative hyponatremia is associated with an increased risk of mortality on the liver transplantation (LT) waiting list. We sought to investigate the impact of pre- and intraoperative serum sodium levels on the one-year mortality after LT. We identified 1,164 patients for whom preoperative and intraoperative serum sodium levels were available. Cox regression analysis with multivariable adjustment was performed for one-year mortality. A propensity score matching analysis was performed for preoperative and intraoperative serum sodium groups to compare one-year survival. The cutoff of sodium level with minimal p-value was 130 mEq/L for both preoperative and intraoperative sodium. Intraoperative hyponatremia was an independent predictor of one-year mortality in the multivariable Cox regression analysis, while preoperative hyponatremia was not. Kaplan-Meier curve showed that there was a significant difference in the one-year mortality between preoperative and intraoperative serum sodium groups. However, after propensity score matching, there was no difference in the one-year mortality among the preoperative sodium groups, while there was a significant difference among the intraoperative sodium groups. Intraoperative hyponatremia defined by mean sodium <130 mEq/L was independently associated with a significantly high one-year mortality. Mean intraoperative serum sodium levels may be a better prognostic predictor than preoperative serum sodium levels.

SUBMITTER: Yang SM

PROVIDER: S-EPMC6303312 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature

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Intraoperative hyponatremia is an independent predictor of one-year mortality after liver transplantation.

Yang Seong-Mi SM Choi Sheung-Nyoung SN Yu Je Hyuk JH Yoon Hyun-Kyu HK Kim Won Ho WH Jung Chul-Woo CW Suh Kyung-Suk KS Lee Kook Hyun KH

Scientific reports 20181221 1

Preoperative hyponatremia is associated with an increased risk of mortality on the liver transplantation (LT) waiting list. We sought to investigate the impact of pre- and intraoperative serum sodium levels on the one-year mortality after LT. We identified 1,164 patients for whom preoperative and intraoperative serum sodium levels were available. Cox regression analysis with multivariable adjustment was performed for one-year mortality. A propensity score matching analysis was performed for preo ...[more]

PMID: 30575797

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Intraoperative hyponatremia is an independent predictor of one-year mortality after liver transplantation.

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Intraoperative hyponatremia is an independent predictor of one-year mortality after liver transplantation.

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