Ontology highlight
ABSTRACT:
SUBMITTER: Bonamy C
PROVIDER: S-EPMC6303337 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Bonamy Clément C Sechet Emmanuel E Amiot Aurélien A Alam Antoine A Mourez Michael M Fraisse Laurent L Sansonetti Philippe J PJ Sperandio Brice B
Scientific reports 20181221 1
The human β-defensin-1 (HBD1) is an antimicrobial peptide constitutively expressed by epithelial cells at mucosal surfaces. In addition to its microbicidal properties, the loss of HBD1 expression in several cancers suggests that it may also have an anti-tumor activity. Here, we investigated the link between HBD1 expression and cancer signaling pathways in the human colon cancer cell lines TC7 and HT-29, and in normal human colonic primary cells, using a mini-gut organoid model. Using available d ...[more]