Dataset Information

Evaluation of the anti-arthritic activity of Cinnamomum cassia bark extract in experimental models.

ABSTRACT:

Background

Cinnamomum cassia iswidely used as a traditional medicinal plant for the treatment of rheumatoid arthritis.

Objective

The present study aimed to assess the anti-arthritic activity of C. cassia bark hydroalcoholic extract (CCHE) in different arthritic animal models.

Methods

In formaldehyde model, sub-plantar administration of 0.1?ml of formaldehyde (2% v/v) into the right hind paws of Wistar albino rats on days 0 and 3. The rats were divided into six groups as follows: normal control, disease control, indomethacin group (3?mg/kg, p.o.) and three groups, treated with 50, 100 and 200?mg/kg CCHE (p.o.). Joint diameter was measured, and ankle joints were collected for MDA and GSH measurements. In complete Freund's adjuvant (CFA)-induced arthritis model, CFA was injected into the sub-plantar surface of the right hind paw in rats. Joint diameter was measured, and serum TNF-? and IL-1? were measured. Histopathological and immunohistochemical analyses were also performed.

Results

CCHE treatment significantly (p?p?p?ConclusionBased on these findings, it can be concluded that C. cassia possesses anti-arthritic properties.

SUBMITTER: Sharma H

PROVIDER: S-EPMC6303416 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature

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Evaluation of the anti-arthritic activity of <i>Cinnamomum cassia</i> bark extract in experimental models.

Sharma Himanshu H Chauhan Prerna P Singh Surender S

Integrative medicine research 20180810 4

<h4>Background</h4><i>Cinnamomum cassia</i> iswidely used as a traditional medicinal plant for the treatment of rheumatoid arthritis.<h4>Objective</h4>The present study aimed to assess the anti-arthritic activity of <i>C. cassia</i> bark hydroalcoholic extract (CCHE) in different arthritic animal models.<h4>Methods</h4>In formaldehyde model, sub-plantar administration of 0.1 ml of formaldehyde (2% v/v) into the right hind paws of Wistar albino rats on days 0 and 3. The rats were divided into six ...[more]

PMID: 30591891

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