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Synthesis and Antibacterial Activity of Polyoxometalates with Different Structures.

ABSTRACT: A new inorganic-organic hybrid compound, [{Cu(phen)₂}₂(H₄W₁₂O₄₀)], was synthesized, and its crystal structure was determined. The Keggin anion H₄W₁₂O₄₀ ^4- was grafted with two coordination units {Cu(phen)₂}, forming an electrically neutral molecule. The antibacterial activity of several polyoxometalate compounds with different anionic structures including the new compound was studied. The results show that the compound 1 can inhibit the growth of Enterococcus faecalis FA2 strains and that antibacterial activity of the polyoxometalate compounds is dependent with component elements of POM but is less relative with the anion structures.

SUBMITTER: Gu J

PROVIDER: S-EPMC6305049 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Synthesis and Antibacterial Activity of Polyoxometalates with Different Structures.

Gu Jingmin J Zhang Lei L Yuan Xiaofeng X Chen Ya-Guang YG Gao Xiuzhu X Li Dong D

Bioinorganic chemistry and applications 20181209

A new inorganic-organic hybrid compound, [{Cu(phen)2}2(H4W12O40)], was synthesized, and its crystal structure was determined. The Keggin anion H4W12O40 4- was grafted with two coordination units {Cu(phen)2}, forming an electrically neutral molecule. The antibacterial activity of several polyoxometalate compounds with different anionic structures including the new compound was studied. Th ...[more]

PMID: 30627139

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Project description:The multifunctional profile of Zn2+ has influenced its great popularity in various pharmaceutical, food, and cosmetic products. Despite the use of different inorganic and organic zinc derivatives, the search for new zinc-containing compounds with a safer skin profile still remains an open issue. The present paper describes the synthesis, structural characterization, and antibacterial activity of zinc(II) complexes with proteinogenic amino acids as potential candidates for dermatological treatments. The obtained complexes are of the general formula [Zn(AA)2], where AA represents an amino acid (L-Glu, Gly, L-His, L-Pro, L-Met, and L-Trp). Their synthesis was designed in such a way that the final bis(aminoacidate) zinc(II) complexes did not contain any counter-ions such as Cl-, NO3-, or SO42- that can cause some skin irritations. The chemical structure and composition of the compounds were identified by 1H NMR spectroscopy and elemental analysis, and four were also characterized by single-crystal X-ray diffraction. The Hirshfeld surface analysis for the Zn2+ metallic center helped to determine its coordination number and geometry for each complex. Finally, the antibacterial properties of the complexes were determined with respect to three Gram-positive strains, viz. Staphylococcus aureus ATCC 6538, Staphylococcus epidermidis ATCC 12228, and Streptococcus pyogenes ATCC 19615, and two Gram-negative bacteria, viz. Escherichia coli ATCC 25992 and Pseudomonas aeruginosa ATCC 27853, and were compared with the activity of zinc 2-pirrolidone 5-carboxylate (ZnPCA), commonly applied in dermatology. It was found that the Zn(II) complexes with methionine and glycine exhibited a higher antibacterial activity than the tested standard, and the antimicrobial properties of complex with Trp were satisfactory. The results of the antimicrobial activity examination allow us to postulate that the obtained zinc complexes might become new active substances for use in dermatological products.

Dataset Information

Synthesis and Antibacterial Activity of Polyoxometalates with Different Structures.

Publications

Synthesis and Antibacterial Activity of Polyoxometalates with Different Structures.

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