Ontology highlight
ABSTRACT:
SUBMITTER: Martinez MD
PROVIDER: S-EPMC7070587 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Molecules (Basel, Switzerland) 20200212 4
Series of novel amides of isoferulic acid, where the phenolic hydroxyl was replaced by a difluoromethyl group, were synthesized and their in vitro antibacterial activities assayed against fourteen bacterial strains (six Gram-positive and eight Gram-negative). A one-pot methodology was developed to obtain the 3'-(difluoromethyl)-4'-methoxycinnamoyl amides using Deoxofluor<sup>®</sup> as a fluorinating agent. The <i>N</i>-isopropyl, <i>N</i>-isopentyl, and <i>N</i>-(2-phenylethyl) amides <b>11b</b ...[more]