Ontology highlight
ABSTRACT:
SUBMITTER: Viswanathan G
PROVIDER: S-EPMC6305072 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Viswanathan Gayathri G Mamazhakypov Argen A Schermuly Ralph T RT Rajagopal Sudarshan S
Frontiers in cardiovascular medicine 20181217
Pressure overload of the right ventricle (RV) in pulmonary arterial hypertension (PAH) leads to RV remodeling and failure, an important determinant of outcome in patients with PAH. Several G protein-coupled receptors (GPCRs) are differentially regulated in the RV myocardium, contributing to the pathogenesis of RV adverse remodeling and dysfunction. Many pharmacological agents that target GPCRs have been demonstrated to result in beneficial effects on left ventricular (LV) failure, such as beta-a ...[more]