Ontology highlight
ABSTRACT:
SUBMITTER: Budka JA
PROVIDER: S-EPMC6305106 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Budka Justin A JA Ferris Mary W MW Capone Matthew J MJ Hollenhorst Peter C PC
Genes & cancer 20180501 5-6
ETS family transcription factors play major roles in prostate tumorigenesis with some acting as oncogenes and others as tumor suppressors. ETS factors can compete for binding at some cis-regulatory sequences, but display specific binding at others. Therefore, changes in expression of ETS family members during tumorigenesis can have complex, multimodal effects. Here we show that ELF1 was the most commonly down-regulated ETS factor in primary prostate tumors, and expression decreased further in me ...[more]