Ontology highlight
ABSTRACT:
SUBMITTER: Long L
PROVIDER: S-EPMC6305110 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Long Long L Zhang Xue X Chen Fuchun F Pan Qi Q Phiphatwatchara Pronnaphat P Zeng Yuyang Y Chen Honglei H
Genes & cancer 20180501 5-6
Cancer immunotherapy and tumor microenvironment have been at the forefront of research over the past decades. Targeting immune checkpoints especially programmed death 1 (PD-1)/programmed death ligand 1 (PD-L1) has made a breakthrough in treating advanced malignancies. However, the low response rate brings a daunting challenge, changing the focus to dig deeply into the tumor microenvironment for alternative therapeutic targets. Strikingly, the inhibitory immune checkpoint lymphocyte activation ge ...[more]