Ontology highlight
ABSTRACT:
SUBMITTER: Meza Gutierrez F
PROVIDER: S-EPMC6305200 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
eLife 20181214
Although polyubiquitin chains linked through all lysines of ubiquitin exist, specific functions are well-established only for lysine-48 and lysine-63 linkages in <i>Saccharomyces cerevisiae</i>. To uncover pathways regulated by distinct linkages, genetic interactions between a gene deletion library and a panel of lysine-to-arginine ubiquitin mutants were systematically identified. The K11R mutant had strong genetic interactions with threonine biosynthetic genes. Consistently, we found that K11R ...[more]