Ontology highlight
ABSTRACT:
SUBMITTER: Pilecki B
PROVIDER: S-EPMC6305334 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Pilecki Bartosz B Wulf-Johansson Helle H Støttrup Christian C Jørgensen Patricia Troest PT Djiadeu Pascal P Nexøe Anders Bathum AB Schlosser Anders A Hansen Søren Werner Karlskov SWK Madsen Jens J Clark Howard William HW Nielsen Claus Henrik CH Vestbo Jørgen J Palaniyar Nades N Holmskov Uffe U Sorensen Grith Lykke GL
Frontiers in immunology 20181218
Cigarette smoke (CS) is the main cause of chronic obstructive pulmonary disease. Surfactant protein D (SP-D) is an important anti-inflammatory protein that regulates host immune defense in the lungs. Here, we investigated the role of SP-D in a murine model of CS-induced inflammation. Pulmonary SP-D localization and abundance was compared between smoker and non-smoker individuals. For <i>in vivo</i> studies, wildtype, and SP-D-deficient mice were exposed to CS for either 12 weeks or 3 days. Moreo ...[more]