Ontology highlight
ABSTRACT:
SUBMITTER: Shivapurkar R
PROVIDER: S-EPMC6305384 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Scientific reports 20181224 1
Glucose is an essential nutrient for Plasmodium falciparum and robust glycolytic activity is indicative of viable parasites. Using NMR spectroscopy, we show that P. falciparum infected erythrocytes consume ~20 times more glucose, and trophozoites metabolize ~6 times more glucose than ring stage parasites. The glycolytic activity, and hence parasite viability, can be measured within a period of 2 h to 5 h, using this method. This facilitates antimalarial bioactivity screening on ring and trophozo ...[more]