Ontology highlight
ABSTRACT:
SUBMITTER: An X
PROVIDER: S-EPMC6305687 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
An Xiang X Zhu Yuanyuan Y Zheng Tongsen T Wang Guangyu G Zhang Minghui M Li Jiade J Ji Hongbo H Li Shijun S Yang Shucai S Xu Dandan D Li Zhiwei Z Wang Tianzhen T He Yan Y Zhang Lei L Yang Weiwei W Zhao Ran R Hao Dapeng D Li Xiaobo X
Molecular therapy. Nucleic acids 20181120
Recent evidence shows that cyclic GMP-AMP synthase (cGAS)/stimulator of interferon (IFN) genes (STING) signaling is essential for antitumor immunity by inducing the production of type I IFN and thus activating both innate and adaptive immunity based on gene knockout mouse models. However, the extensive detection of the expression of cGAS/STING signaling in human cancer and mining the roles of this signaling pathway in human cancer immunity have not been performed until now. In this study, we rev ...[more]