Ontology highlight
ABSTRACT:
SUBMITTER: Skon-Hegg C
PROVIDER: S-EPMC6305794 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Skon-Hegg Cara C Zhang Juan J Wu Xiumin X Sagolla Meredith M Ota Naruhisa N Wuster Arthur A Tom Jennifer J Doran Emma E Ramamoorthi Nandhini N Caplazi Patrick P Monroe John J Lee Wyne P WP Behrens Timothy W TW
Journal of immunology (Baltimore, Md. : 1950) 20181203 1
Both common and rare genetic variants of laccase domain-containing 1 (<i>LACC1</i>, previously C13orf31) are associated with inflammatory bowel disease, leprosy, Behcet disease, and systemic juvenile idiopathic arthritis. However, the functional relevance of these variants is unclear. In this study, we use LACC1-deficient mice to gain insight into the role of LACC1 in regulating inflammation. Following oral administration of <i>Citrobacter rodentium</i>, LACC1 knockout (KO) mice had more severe ...[more]