Ontology highlight
ABSTRACT:
SUBMITTER: Liu J
PROVIDER: S-EPMC6307757 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Liu Jie J Li Juan J Li Pingping P Jiang Yina Y Chen He H Wang Ruiqi R Cao Fang F Liu Peijun P
Journal of cellular and molecular medicine 20181118 1
Tamoxifen (TAM) is a primary drug for treatment of estrogen receptor positive breast cancer. However, TAM resistance remains a serious threat to breast cancer patients and may be attributed to increased stemness of breast cancer. Here, we show that discs large homolog 5 (DLG5) expression is down-regulated in TAM-resistant breast cancer and cells. DLG5 silencing decreased the sensitivity to TAM and increased the frequency and stemness of CD44<sup>+</sup> /CD24<sup>-</sup> breast cancer stem cells ...[more]