Ontology highlight
ABSTRACT:
SUBMITTER: Drown BS
PROVIDER: S-EPMC6309520 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Cell chemical biology 20181011 12
The post-translational modification (PTM) and signaling molecule poly(ADP-ribose) (PAR) has an impact on diverse biological processes. This PTM is regulated by a series of ADP-ribosyl glycohydrolases (PARG enzymes) that cleave polymers and/or liberate monomers from their protein targets. Existing methods for monitoring these hydrolases rely on detection of the natural substrate, PAR, commonly achieved via radioisotopic labeling. Here we disclose a general substrate for monitoring PARG activity, ...[more]