Ontology highlight
ABSTRACT:
SUBMITTER: Osborne MJ
PROVIDER: S-EPMC6309593 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Osborne Michael J MJ Coutinho de Oliveira Luciana L Volpon Laurent L Borden Katherine L B KLB
Biomolecular NMR assignments 20180622 2
A major component of phase II drug metabolism is the covalent addition of glucuronic acid to metabolites and xenobiotics. This activity is carried out by UDP-glucuronosyltransferases (UGT) which bind the UDP-glucuronic acid donor and catalyze the covalent addition of glucuronic acid sugar moieties onto a wide variety of substrates. UGTs play important roles in drug detoxification and were recently shown to act in an inducible form of multi-drug resistance in cancer patients. Despite their biolog ...[more]