Shotgun Metagenomics of 250 Adult Twins Reveals Genetic and Environmental Impacts on the Gut Microbiome.
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ABSTRACT:
SUBMITTER: Xie H
PROVIDER: S-EPMC6309625 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Publications
Shotgun Metagenomics of 250 Adult Twins Reveals Genetic and Environmental Impacts on the Gut Microbiome.
Xie Hailiang H Guo Ruijin R Zhong Huanzi H Feng Qiang Q Lan Zhou Z Qin Bingcai B Ward Kirsten J KJ Jackson Matthew A MA Xia Yan Y Chen Xu X Chen Bing B Xia Huihua H Xu Changlu C Li Fei F Xu Xun X Al-Aama Jumana Yousuf JY Yang Huanming H Wang Jian J Kristiansen Karsten K Wang Jun J Steves Claire J CJ Bell Jordana T JT Li Junhua J Spector Timothy D TD Jia Huijue H
Cell systems 20161103 6
The gut microbiota has been typically viewed as an environmental factor for human health. Twins are well suited for investigating the concordance of their gut microbiomes and decomposing genetic and environmental influences. However, existing twin studies utilizing metagenomic shotgun sequencing have included only a few samples. Here, we sequenced fecal samples from 250 adult twins in the TwinsUK registry and constructed a comprehensive gut microbial reference gene catalog. We demonstrate herita ...[more]
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