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Elucidation of the structure of retroviral proteases: a reminiscence.

ABSTRACT: Determinations of only a very few protein structures had consequences comparable to the impact exerted by the structure of the protease encoded by HIV-1, published just over 25 years ago. The structure of this relatively small protein and its cousins from other retroviruses provided a clear target for a spectacularly successful structure-assisted drug design effort that offered new hope for controlling the then-escalating AIDS epidemic. This reminiscence is limited primarily to work conducted at the National Cancer Institute, and is not meant to be a comprehensive history of the field, but is rather an attempt to provide a very personal account of how the structures of this most thoroughly studied crystallographic target were determined.

SUBMITTER: Jaskolski M

PROVIDER: S-EPMC6310002 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature

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Elucidation of the structure of retroviral proteases: a reminiscence.

Jaskolski Mariusz M Miller Maria M Mohana Rao J K JK Gustchina Alla A Wlodawer Alexander A

The FEBS journal 20150828 21

Determinations of only a very few protein structures had consequences comparable to the impact exerted by the structure of the protease encoded by HIV-1, published just over 25 years ago. The structure of this relatively small protein and its cousins from other retroviruses provided a clear target for a spectacularly successful structure-assisted drug design effort that offered new hope for controlling the then-escalating AIDS epidemic. This reminiscence is limited primarily to work conducted at ...[more]

PMID: 26258480

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