Ontology highlight
ABSTRACT: Background
Interferon-gamma (IFN-γ) release assays (IGRAs) are used to diagnose tuberculosis (TB) but not to measure treatment response.Objective
To measure IFN-γ response to active anti-tuberculosis treatment.Design
Patients from the Henan Provincial Chest Hospital, Henan, China, with TB symptoms and/or signs were enrolled into this prospective, observational cohort study and followed for 6 months of treatment, with blood and sputum samples collected at 0, 2, 4, 6, 8, 16 and 24 weeks. The QuantiFERON® TB-Gold assay was run on collected blood samples. Participants received a follow-up telephone call at 24 months to determine relapse status.Results
Of the 152 TB patients enrolled, 135 were eligible for this analysis: 118 pulmonary (PTB) and 17 extra-pulmonary TB (EPTB) patients. IFN-γ levels declined significantly over time among all patients (P = 0.002), with this decline driven by PTB patients (P = 0.001), largely during the initial 8 weeks of treatment (P = 0.019). IFN-γ levels did not change among EPTB patients over time or against baseline culture or drug resistance status.Conclusion
After 6 months of effective anti-tuberculosis treatment, IFN-γ levels decreased significantly in PTB patients, largely over the initial 8 weeks of treatment. IFN-γ concentrations may offer some value for monitoring anti-tuberculosis treatment response among PTB patients.
SUBMITTER: Liang L
PROVIDER: S-EPMC6310125 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Liang L L Shi R R Liu X X Yuan X X Zheng S S Zhang G G Wang W W Wang J J England K K Via L E LE Cai Y Y Goldfeder L C LC Dodd L E LE Barry C E CE Chen R Y RY
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 20171001 10
<h4>Background</h4>Interferon-gamma (IFN-γ) release assays (IGRAs) are used to diagnose tuberculosis (TB) but not to measure treatment response.<h4>Objective</h4>To measure IFN-γ response to active anti-tuberculosis treatment.<h4>Design</h4>Patients from the Henan Provincial Chest Hospital, Henan, China, with TB symptoms and/or signs were enrolled into this prospective, observational cohort study and followed for 6 months of treatment, with blood and sputum samples collected at 0, 2, 4, 6, 8, 16 ...[more]