Ontology highlight
ABSTRACT:
SUBMITTER: Bharti R
PROVIDER: S-EPMC7581375 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Bharti Reena R Srivastava Ashish A Roy Trisha T Verma Khushboo K Reddy D V Siva DVS Shafi Hasham H Verma Sonia S Raman Sunil K SK Singh Amit K AK Singh Jyotsna J Ray Lipika L Misra Amit A
Molecular therapy. Nucleic acids 20201022
Nebulized gamma interferon (IFN-γ) protein has been studied for clinical safety and efficacy against pulmonary tuberculosis (TB). The protein is expensive, requires a cold chain, and is difficult to deploy in limited-resource, high-incidence settings. We generated a preclinical proof of concept (PoC) for a dry powder inhalation (DPI) containing DNA constructs to transiently transfect the lung and airway epithelium of mice with murine IFN-γ. Bacterial colony-forming units (CFU) in the lungs of mi ...[more]