Ontology highlight
ABSTRACT:
SUBMITTER: Tang Y
PROVIDER: S-EPMC6311529 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Tang Yong Y Joo Donghyun D Liu Guangna G Tu Hailin H You Jeffrey J Jin Jianping J Zhao Xueqiang X Hung Mien-Chie MC Lin Xin X
The Journal of biological chemistry 20181025 52
The linear ubiquitin chain assembly complex (LUBAC) regulates NF-κB activation by modifying proteins with linear (M1-linked) ubiquitination chains. Although LUBAC also regulates the apoptosis pathway, the precise mechanism by which LUBAC regulates apoptosis remains not fully defined. Here, we report that LUBAC-mediated M1-linked ubiquitination of cellular FLICE-like inhibitory protein (cFLIP), an anti-apoptotic molecule, contributes to tumor necrosis factor (TNF) α-induced apoptosis. We found th ...[more]