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Formation of Complex ?-Imino Esters via Multihetero-Cope Rearrangement of ?-Keto Ester Derived Nitrones.

ABSTRACT: A sequential benzoylation and multihetero-Cope rearrangement of ?-keto ester derived nitrones has been developed. The reaction furnishes a diverse array of complex ?-imino ester derivatives. The products can be transformed into amino alcohols via LiAlH4 reduction.

SUBMITTER: Bartlett SL

PROVIDER: S-EPMC6311990 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature

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Formation of Complex α-Imino Esters via Multihetero-Cope Rearrangement of α-Keto Ester Derived Nitrones.

Bartlett Samuel L SL Keiter Kimberly M KM Zavesky Blane P BP Johnson Jeffrey S JS

Synthesis 20181206 1

A sequential benzoylation and multihetero-Cope rearrangement of α-keto ester derived nitrones has been developed. The reaction furnishes a diverse array of complex α-imino ester derivatives. The products can be transformed into amino alcohols via LiAlH<sub>4</sub> reduction. ...[more]

PMID: 30607036

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