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RAB10: an Alzheimer's disease resilience locus and potential drug target.

ABSTRACT: Alzheimer's disease (AD) is mainly a late-onset neurodegenerative disorder. Substantial efforts have been made to solve the complex genetic architecture of AD as a means to identify therapeutic targets. Unfortunately, to date, no disease-altering therapeutics have been developed. As therapeutics are likely to be most effective in the early stages of disease (ie, before the onset of symptoms), a recent focus of AD research has been the identification of protective factors that prevent disease. One example is the discovery of a rare variant in the 3'-UTR of RAB10 that is protective for AD. Here, we review the possible genetic, molecular, and functional role of RAB10 in AD and potential therapeutic approaches to target RAB10.

SUBMITTER: Tavana JP

PROVIDER: S-EPMC6312396 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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RAB10: an Alzheimer's disease resilience locus and potential drug target.

Tavana Justina P JP Rosene Matthew M Jensen Nick O NO Ridge Perry G PG Kauwe John Sk JS Karch Celeste M CM

Clinical interventions in aging 20181228

Alzheimer's disease (AD) is mainly a late-onset neurodegenerative disorder. Substantial efforts have been made to solve the complex genetic architecture of AD as a means to identify therapeutic targets. Unfortunately, to date, no disease-altering therapeutics have been developed. As therapeutics are likely to be most effective in the early stages of disease (ie, before the onset of symptoms), a recent focus of AD research has been the identification of protective factors that prevent disease. On ...[more]

PMID: 30643396

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