A transcriptome-wide association study of 229,000 women identifies new candidate susceptibility genes for breast cancer.
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ABSTRACT:
SUBMITTER: Wu L
PROVIDER: S-EPMC6314198 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Publications
A transcriptome-wide association study of 229,000 women identifies new candidate susceptibility genes for breast cancer.
Wu Lang L Shi Wei W Long Jirong J Guo Xingyi X Michailidou Kyriaki K Beesley Jonathan J Bolla Manjeet K MK Shu Xiao-Ou XO Lu Yingchang Y Cai Qiuyin Q Al-Ejeh Fares F Rozali Esdy E Wang Qin Q Dennis Joe J Li Bingshan B Zeng Chenjie C Feng Helian H Gusev Alexander A Barfield Richard T RT Andrulis Irene L IL Anton-Culver Hoda H Arndt Volker V Aronson Kristan J KJ Auer Paul L PL Barrdahl Myrto M Baynes Caroline C Beckmann Matthias W MW Benitez Javier J Bermisheva Marina M Blomqvist Carl C Bogdanova Natalia V NV Bojesen Stig E SE Brauch Hiltrud H Brenner Hermann H Brinton Louise L Broberg Per P Brucker Sara Y SY Burwinkel Barbara B Caldés Trinidad T Canzian Federico F Carter Brian D BD Castelao J Esteban JE Chang-Claude Jenny J Chen Xiaoqing X Cheng Ting-Yuan David TD Christiansen Hans H Clarke Christine L CL Collée Margriet M Cornelissen Sten S Couch Fergus J FJ Cox David D Cox Angela A Cross Simon S SS Cunningham Julie M JM Czene Kamila K Daly Mary B MB Devilee Peter P Doheny Kimberly F KF Dörk Thilo T Dos-Santos-Silva Isabel I Dumont Martine M Dwek Miriam M Eccles Diana M DM Eilber Ursula U Eliassen A Heather AH Engel Christoph C Eriksson Mikael M Fachal Laura L Fasching Peter A PA Figueroa Jonine J Flesch-Janys Dieter D Fletcher Olivia O Flyger Henrik H Fritschi Lin L Gabrielson Marike M Gago-Dominguez Manuela M Gapstur Susan M SM García-Closas Montserrat M Gaudet Mia M MM Ghoussaini Maya M Giles Graham G GG Goldberg Mark S MS Goldgar David E DE González-Neira Anna A Guénel Pascal P Hahnen Eric E Haiman Christopher A CA Håkansson Niclas N Hall Per P Hallberg Emily E Hamann Ute U Harrington Patricia P Hein Alexander A Hicks Belynda B Hillemanns Peter P Hollestelle Antoinette A Hoover Robert N RN Hopper John L JL Huang Guanmengqian G Humphreys Keith K Hunter David J DJ Jakubowska Anna A Janni Wolfgang W John Esther M EM Johnson Nichola N Jones Kristine K Jones Michael E ME Jung Audrey A Kaaks Rudolf R Kerin Michael J MJ Khusnutdinova Elza E Kosma Veli-Matti VM Kristensen Vessela N VN Lambrechts Diether D Le Marchand Loic L Li Jingmei J Lindström Sara S Lissowska Jolanta J Lo Wing-Yee WY Loibl Sibylle S Lubinski Jan J Luccarini Craig C Lux Michael P MP MacInnis Robert J RJ Maishman Tom T Kostovska Ivana Maleva IM Mannermaa Arto A Manson JoAnn E JE Margolin Sara S Mavroudis Dimitrios D Meijers-Heijboer Hanne H Meindl Alfons A Menon Usha U Meyer Jeffery J Mulligan Anna Marie AM Neuhausen Susan L SL Nevanlinna Heli H Neven Patrick P Nielsen Sune F SF Nordestgaard Børge G BG Olopade Olufunmilayo I OI Olson Janet E JE Olsson Håkan H Peterlongo Paolo P Peto Julian J Plaseska-Karanfilska Dijana D Prentice Ross R Presneau Nadege N Pylkäs Katri K Rack Brigitte B Radice Paolo P Rahman Nazneen N Rennert Gad G Rennert Hedy S HS Rhenius Valerie V Romero Atocha A Romm Jane J Rudolph Anja A Saloustros Emmanouil E Sandler Dale P DP Sawyer Elinor J EJ Schmidt Marjanka K MK Schmutzler Rita K RK Schneeweiss Andreas A Scott Rodney J RJ Scott Christopher G CG Seal Sheila S Shah Mitul M Shrubsole Martha J MJ Smeets Ann A Southey Melissa C MC Spinelli John J JJ Stone Jennifer J Surowy Harald H Swerdlow Anthony J AJ Tamimi Rulla M RM Tapper William W Taylor Jack A JA Terry Mary Beth MB Tessier Daniel C DC Thomas Abigail A Thöne Kathrin K Tollenaar Rob A E M RAEM Torres Diana D Truong Thérèse T Untch Michael M Vachon Celine C Van Den Berg David D Vincent Daniel D Waisfisz Quinten Q Weinberg Clarice R CR Wendt Camilla C Whittemore Alice S AS Wildiers Hans H Willett Walter C WC Winqvist Robert R Wolk Alicja A Xia Lucy L Yang Xiaohong R XR Ziogas Argyrios A Ziv Elad E Dunning Alison M AM Pharoah Paul D P PDP Simard Jacques J Milne Roger L RL Edwards Stacey L SL Kraft Peter P Easton Douglas F DF Chenevix-Trench Georgia G Zheng Wei W
Nature genetics 20180618 7
The breast cancer risk variants identified in genome-wide association studies explain only a small fraction of the familial relative risk, and the genes responsible for these associations remain largely unknown. To identify novel risk loci and likely causal genes, we performed a transcriptome-wide association study evaluating associations of genetically predicted gene expression with breast cancer risk in 122,977 cases and 105,974 controls of European ancestry. We used data from the Genotype-Tis ...[more]