Ontology highlight
ABSTRACT:
SUBMITTER: Atkins I
PROVIDER: S-EPMC6522343 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Atkins Isabelle I Kinnersley Ben B Ostrom Quinn T QT Labreche Karim K Il'yasova Dora D Armstrong Georgina N GN Eckel-Passow Jeanette E JE Schoemaker Minouk J MJ Nöthen Markus M MM Barnholtz-Sloan Jill S JS Swerdlow Anthony J AJ Simon Matthias M Rajaraman Preetha P Chanock Stephen J SJ Shildkraut Joellen J Bernstein Jonine L JL Hoffmann Per P Jöckel Karl-Heinz KH Lai Rose K RK Claus Elizabeth B EB Olson Sara H SH Johansen Christoffer C Wrensch Margaret R MR Melin Beatrice B Jenkins Robert B RB Sanson Marc M Bondy Melissa L ML Houlston Richard S RS
Cancer research 20190201 8
Genome-wide association studies (GWAS) have so far identified 25 loci associated with glioma risk, with most showing specificity for either glioblastoma (GBM) or non-GBM tumors. The majority of these GWAS susceptibility variants reside in noncoding regions and the causal genes underlying the associations are largely unknown. Here we performed a transcriptome-wide association study to search for novel risk loci and candidate causal genes at known GWAS loci using Genotype-Tissue Expression Project ...[more]