Serum androgen profiles in women with premature ovarian insufficiency: a systematic review and meta-analysis.
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ABSTRACT: Objective
This meta-analysis aims to investigate serum androgen profiles (testosterone, dehydroepiandrosterone sulfate, androstenedione, and sex hormone-binding globulin) in women with premature ovarian failure and to establish if there is evidence of diminished androgen levels in these women.Methods
Various Internet sources of PubMed, Cochrane library, and Medline were searched systematically until February, 2018. Out of a pool of 2,461 studies, after applying the inclusion/exclusion criterion, 14, 8, 10, and 9 studies were chosen for testosterone, dehydroepiandrosterone sulfate, androstenedione, and sex hormone-binding globulin, respectively, for this meta-analysis. The effect measure was the standardized mean difference with 95% confidence interval (95% CI) in a random-effects model.Results
The testosterone concentrations in premature ovarian insufficiency were compared with fertile controls: stamdard mean difference (IV, random, 95% CI) -0.73 [-0.99, -0.46], P value?ConclusionsWomen with premature ovarian insufficiency are at risk for decreased concentrations of testosterone, dehydroepiandrosterone sulfate, and androstenedione. Dehydroepiandrosterone sulfate levels were more reduced in postmenopausal controls when compared with premature ovarian insufficiency cases.
SUBMITTER: Soman M
PROVIDER: S-EPMC6314630 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Publications
Serum androgen profiles in women with premature ovarian insufficiency: a systematic review and meta-analysis.
Soman Midhun M Huang Li-Cong LC Cai Wen-Hui WH Xu Jun-Bi JB Chen Jun-Yao JY He Ren-Ke RK Ruan Heng-Chao HC Xu Xiang-Rong XR Qian Zhi-Da ZD Zhu Xiao-Ming XM
Menopause (New York, N.Y.) 20190101 1
<h4>Objective</h4>This meta-analysis aims to investigate serum androgen profiles (testosterone, dehydroepiandrosterone sulfate, androstenedione, and sex hormone-binding globulin) in women with premature ovarian failure and to establish if there is evidence of diminished androgen levels in these women.<h4>Methods</h4>Various Internet sources of PubMed, Cochrane library, and Medline were searched systematically until February, 2018. Out of a pool of 2,461 studies, after applying the inclusion/excl ...[more]
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