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Health-related quality-of-life among patients with premature ovarian insufficiency: a systematic review and meta-analysis.

ABSTRACT: PURPOSE:To systematically review studies investigating health-related quality-of-life (HrQoL) in patients with premature ovarian insufficiency (POI), to examine questionnaires used and to conduct a meta-analysis of control studies with normal ovarian function. METHODS:Data sources: PubMed, Embase, Web of science, CNKI, and CQVIP, searched from inception until June 2018. The search strategy was a combination of medical (e.g. POI), subjective (e.g. well-being) and methodological (e.g. questionnaires) keywords. PRISMA guidelines were used to assess outcome data quality/validity by one reviewer, verified by a second reviewer. Risk of bias within studies was evaluated. A meta-analysis compared HrQoL in patients and non-patients. Due to measurement differences in the studies, the effect size was calculated as standard mean difference. RESULTS:We identified 6869 HrQoL studies. Nineteen geographically diverse studies met inclusion criteria, dated from 2006, using 23 questionnaires. The meta-analysis included six studies with 645 POI participants (age 33.3?±?5.47) and 492 normal-ovarian control subjects (age 32.87?±?5.61). Medium effect sizes were found for lower overall HrQoL (pooled SMD?=?-?0.73, 95% CI -?0.94, -?0.51; I2 =?54%) and physical function (pooled SMD?=?-?0.54, 95% CI -?0.69, -?0.39; I2 =?55%). Heterogeneity was investigated. Effect sizes varied for sexual function depending on the measure (SMD?=?-?0.27 to -?0.74), overall HrQoL (SF-36) had the largest effect size (-?0.93) in one study. The effect sizes for psychological and social HrQoL were small. CONCLUSION:POI is associated with low-to-medium effect size on HrQoL compared to normal ovarian controls. The greatest effects are found in general HrQoL and most sexual function areas. Condition-specific questionnaires and RCTs are recommended for further investigation.

SUBMITTER: Li XT

PROVIDER: S-EPMC6962283 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature

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Health-related quality-of-life among patients with premature ovarian insufficiency: a systematic review and meta-analysis.

Li X T XT Li P Y PY Liu Y Y Yang H S HS He L Y LY Fang Y G YG Liu J J Liu B Y BY Chaplin J E JE

Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation 20191016 1

<h4>Purpose</h4>To systematically review studies investigating health-related quality-of-life (HrQoL) in patients with premature ovarian insufficiency (POI), to examine questionnaires used and to conduct a meta-analysis of control studies with normal ovarian function.<h4>Methods</h4>Data sources: PubMed, Embase, Web of science, CNKI, and CQVIP, searched from inception until June 2018. The search strategy was a combination of medical (e.g. POI), subjective (e.g. well-being) and methodological (e. ...[more]

PMID: 31620985

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Health-related quality-of-life among patients with premature ovarian insufficiency: a systematic review and meta-analysis.

Publications

Health-related quality-of-life among patients with premature ovarian insufficiency: a systematic review and meta-analysis.

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