Ontology highlight
ABSTRACT:
SUBMITTER: Shao Z
PROVIDER: S-EPMC6314811 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Shao Zhuzhou Z Liu Wei W Tao Huimin H Liu Fang F Zeng Ruxin R Champagne Pier Alexandre PA Cao Yang Y Houk K N KN Liang Yong Y
Chemical communications (Cambridge, England) 20181201 100
Sulfonamide derivatives have been used in pharmaceutics for decades. Here we report a new approach to release sulfonamides efficiently using a bioorthogonal reaction of sulfonyl sydnonimines and dibenzoazacyclooctyne (DIBAC). The second-order rate constant of the cycloaddition reaction can be up to 0.62 M-1 s-1, and the reactants are highly stable under physiological conditions. Most significantly, we also discovered the mutual orthogonality between the sydnonimine-DIBAC and benzonorbornadiene-t ...[more]