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A Divergent Hepatitis D-Like Agent in Birds.

ABSTRACT: Hepatitis delta virus (HDV) is currently only found in humans and is a satellite virus that depends on hepatitis B virus (HBV) envelope proteins for assembly, release, and entry. Using meta-transcriptomics, we identified the genome of a novel HDV-like agent in ducks. Sequence analysis revealed secondary structures that were shared with HDV, including self-complementarity and ribozyme features. The predicted viral protein shares 32% amino acid similarity to the small delta antigen of HDV and comprises a divergent phylogenetic lineage. The discovery of an avian HDV-like agent has important implications for the understanding of the origins of HDV and sub-viral agents.

SUBMITTER: Wille M

PROVIDER: S-EPMC6315422 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature

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A Divergent Hepatitis D-Like Agent in Birds.

Wille Michelle M Netter Hans J HJ Littlejohn Margaret M Yuen Lilly L Shi Mang M Eden John-Sebastian JS Klaassen Marcel M Holmes Edward C EC Hurt Aeron C AC

Viruses 20181217 12

Hepatitis delta virus (HDV) is currently only found in humans and is a satellite virus that depends on hepatitis B virus (HBV) envelope proteins for assembly, release, and entry. Using meta-transcriptomics, we identified the genome of a novel HDV-like agent in ducks. Sequence analysis revealed secondary structures that were shared with HDV, including self-complementarity and ribozyme features. The predicted viral protein shares 32% amino acid similarity to the small delta antigen of HDV and comp ...[more]

PMID: 30562970

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