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Bromopyrrole Alkaloids from the Sponge Agelas kosrae.

ABSTRACT: Two new sceptrin derivatives (1,2) and eight structurally-related known bromopyrrole-bearing alkaloids were isolated from the tropical sponge Agelas kosrae. By a combination of spectroscopic methods, the new compounds, designated dioxysceptrin (1) and ageleste C (2), were determined to be structural analogs of each other that differ at the imidazole moiety. Dioxysceptrin was also found to exist as a mixture of ?-amido epimers. The sceptrin alkaloids exhibited weak cytotoxicity against cancer cells. Compounds 1 and 2 also moderately exhibited anti-angiogenic and isocitrate lyase-inhibitory activities, respectively.

SUBMITTER: Kwon OS

PROVIDER: S-EPMC6316234 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature

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Bromopyrrole Alkaloids from the Sponge Agelas kosrae.

Kwon Oh-Seok OS Kim Donghwa D Kim Heegyu H Lee Yeon-Ju YJ Lee Hyi-Seung HS Sim Chung J CJ Oh Dong-Chan DC Lee Sang Kook SK Oh Ki-Bong KB Shin Jongheon J

Marine drugs 20181217 12

Two new sceptrin derivatives (1,2) and eight structurally-related known bromopyrrole-bearing alkaloids were isolated from the tropical sponge Agelas kosrae. By a combination of spectroscopic methods, the new compounds, designated dioxysceptrin (1) and ageleste C (2), were determined to be structural analogs of each other that differ at the imidazole moiety. Dioxysceptrin was also found to exist as a mixture of α-amido epimers. The sceptrin alkaloids exhibited w ...[more]

PMID: 30563015

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