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Antimicrobial metabolites from the Paracel Islands sponge Agelas mauritiana.

ABSTRACT: Four new alkaloids, (-)-8'-oxo-agelasine D (2), ageloxime B (3), (+)-2-oxo-agelasidine C (4), and 4-bromo-N-(butoxymethyl)-1H-pyrrole-2-carboxamide (5), and the known compound (-)-ageloxime D (1) were isolated from the marine sponge Agelas mauritiana. Their chemical structures were established on the basis of spectroscopic analysis. Compounds 1 and 3 both showed antifungal activity against Cryptococcus neoformans and antileishmanial activity against Leishmania donovani in vitro. Compound 3 also exhibited antibacterial activity against Staphylococcus aureus and methicillin-resistant S. aureusin vitro.

SUBMITTER: Yang F

PROVIDER: S-EPMC4883697 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature

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Antimicrobial metabolites from the Paracel Islands sponge Agelas mauritiana.

Yang Fan F Hamann Mark T MT Zou Yike Y Zhang Ming-Yu MY Gong Xiao-Bin XB Xiao Jian-Ru JR Chen Wan-Sheng WS Lin Hou-Wen HW

Journal of natural products 20120223 4

Four new alkaloids, (-)-8'-oxo-agelasine D (2), ageloxime B (3), (+)-2-oxo-agelasidine C (4), and 4-bromo-N-(butoxymethyl)-1H-pyrrole-2-carboxamide (5), and the known compound (-)-ageloxime D (1) were isolated from the marine sponge Agelas mauritiana. Their chemical structures were established on the basis of spectroscopic analysis. Compounds 1 and 3 both showed antifungal activity against Cryptococcus neoformans and antileishmanial activity against Leishmania donovani in vitro. Compound 3 also ...[more]

PMID: 22360686

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