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Antimicrobial metabolites from the Paracel Islands sponge Agelas mauritiana.


ABSTRACT: Four new alkaloids, (-)-8'-oxo-agelasine D (2), ageloxime B (3), (+)-2-oxo-agelasidine C (4), and 4-bromo-N-(butoxymethyl)-1H-pyrrole-2-carboxamide (5), and the known compound (-)-ageloxime D (1) were isolated from the marine sponge Agelas mauritiana. Their chemical structures were established on the basis of spectroscopic analysis. Compounds 1 and 3 both showed antifungal activity against Cryptococcus neoformans and antileishmanial activity against Leishmania donovani in vitro. Compound 3 also exhibited antibacterial activity against Staphylococcus aureus and methicillin-resistant S. aureusin vitro.

SUBMITTER: Yang F 

PROVIDER: S-EPMC4883697 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature

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Antimicrobial metabolites from the Paracel Islands sponge Agelas mauritiana.

Yang Fan F   Hamann Mark T MT   Zou Yike Y   Zhang Ming-Yu MY   Gong Xiao-Bin XB   Xiao Jian-Ru JR   Chen Wan-Sheng WS   Lin Hou-Wen HW  

Journal of natural products 20120223 4


Four new alkaloids, (-)-8'-oxo-agelasine D (2), ageloxime B (3), (+)-2-oxo-agelasidine C (4), and 4-bromo-N-(butoxymethyl)-1H-pyrrole-2-carboxamide (5), and the known compound (-)-ageloxime D (1) were isolated from the marine sponge Agelas mauritiana. Their chemical structures were established on the basis of spectroscopic analysis. Compounds 1 and 3 both showed antifungal activity against Cryptococcus neoformans and antileishmanial activity against Leishmania donovani in vitro. Compound 3 also  ...[more]

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