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Mechanisms of DNA Methyltransferase Recruitment in Mammals.

ABSTRACT: DNA methylation is an essential epigenetic mark in mammals. The proper distribution of this mark depends on accurate deposition and maintenance mechanisms, and underpins its functional role. This, in turn, depends on the precise recruitment and activation of de novo and maintenance DNA methyltransferases (DNMTs). In this review, we discuss mechanisms of recruitment of DNMTs by transcription factors and chromatin modifiers-and by RNA-and place these mechanisms in the context of biologically meaningful epigenetic events. We present hypotheses and speculations for future research, and underline the fundamental and practical benefits of better understanding the mechanisms that govern the recruitment of DNMTs.

SUBMITTER: Laisne M

PROVIDER: S-EPMC6316769 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature

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Mechanisms of DNA Methyltransferase Recruitment in Mammals.

Laisné Marthe M Gupta Nikhil N Kirsh Olivier O Pradhan Sriharsa S Defossez Pierre-Antoine PA

Genes 20181210 12

DNA methylation is an essential epigenetic mark in mammals. The proper distribution of this mark depends on accurate deposition and maintenance mechanisms, and underpins its functional role. This, in turn, depends on the precise recruitment and activation of de novo and maintenance DNA methyltransferases (DNMTs). In this review, we discuss mechanisms of recruitment of DNMTs by transcription factors and chromatin modifiers-and by RNA-and place these mechanisms in the context of biologically meani ...[more]

PMID: 30544749

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