PH-Induced Folding of the Caspase-Cleaved Par-4 Tumor Suppressor: Evidence of Structure Outside of the Coiled Coil Domain.
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ABSTRACT:
SUBMITTER: Clark AM
PROVIDER: S-EPMC6316887 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Publications
pH-Induced Folding of the Caspase-Cleaved Par-4 Tumor Suppressor: Evidence of Structure Outside of the Coiled Coil Domain.
Clark Andrea M AM Ponniah Komala K Warden Meghan S MS Raitt Emily M EM Yawn Andrea C AC Pascal Steven M SM
Biomolecules 20181204 4
Prostate apoptosis response-4 (Par-4) is a 38 kDa largely intrinsically disordered tumor suppressor protein that functions in cancer cell apoptosis. Par-4 down-regulation is often observed in cancer while up-regulation is characteristic of neurodegenerative conditions such as Alzheimer's disease. Cleavage of Par-4 by caspase-3 activates tumor suppression via formation of an approximately 25 kDa fragment (cl-Par-4) that enters the nucleus and inhibits Bcl-2 and NF-ƙB, which function in pro-surviv ...[more]
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