Structural remodeling and conduction velocity dynamics in the human left atrium: Relationship with reentrant mechanisms sustaining atrial fibrillation.

ABSTRACT:

Background

Rate-dependent conduction velocity (CV) slowing is associated with atrial fibrillation (AF) initiation and reentrant mechanisms.

Objective

The purpose of this study was to assess the relationship between bipolar voltage, CV dynamics, and AF drivers.

Methods

Patients undergoing catheter ablation for persistent AF (<24 months) were enrolled. Unipolar electrograms were recorded with a 64-pole basket catheter during atrial pacing at 4 pacing intervals (PIs) during sinus rhythm. CVs were measured between pole pairs along the wavefront path and correlated with underlying bipolar voltage. CV dynamics within low-voltage zones (LVZs <0.5 mV) were compared to those of non-LVZs (≥0.5 mV) and were correlated to driver sites mapped using CARTOFINDER (Biosense Webster).<

SUBMITTER: Honarbakhsh S 

PROVIDER: S-EPMC6317307 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature