Ontology highlight
ABSTRACT:
SUBMITTER: Gussak G
PROVIDER: S-EPMC6824299 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Gussak Georg G Pfenniger Anna A Wren Lisa L Gilani Mehul M Zhang Wenwei W Yoo Shin S Johnson David A DA Burrell Amy A Benefield Brandon B Knight Gabriel G Knight Bradley P BP Passman Rod R Goldberger Jeffrey J JJ Aistrup Gary G Wasserstrom J Andrew JA Shiferaw Yohannes Y Arora Rishi R
JCI insight 20191017 20
Atrial fibrillation (AF) is the most common heart rhythm disorder and a major cause of stroke. Unfortunately, current therapies for AF are suboptimal, largely because the molecular mechanisms underlying AF are poorly understood. Since the autonomic nervous system is thought to increase vulnerability to AF, we used a rapid atrial pacing (RAP) canine model to investigate the anatomic and electrophysiological characteristics of autonomic remodeling in different regions of the left atrium. RAP led t ...[more]