Enhanced lubrication on tissue and biomaterial surfaces through peptide-mediated binding of hyaluronic acid.
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SUBMITTER: Singh A
PROVIDER: S-EPMC6317357 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
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Enhanced lubrication on tissue and biomaterial surfaces through peptide-mediated binding of hyaluronic acid.
Singh Anirudha A Corvelli Michael M Unterman Shimon A SA Wepasnick Kevin A KA McDonnell Peter P Elisseeff Jennifer H JH
Nature materials 20140803 10
Lubrication is key for the efficient function of devices and tissues with moving surfaces, such as articulating joints, ocular surfaces and the lungs. Indeed, lubrication dysfunction leads to increased friction and degeneration of these systems. Here, we present a polymer-peptide surface coating platform to non-covalently bind hyaluronic acid (HA), a natural lubricant in the body. Tissue surfaces treated with the HA-binding system exhibited higher lubricity values, and in vivo were able to retai ...[more]
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