Ontology highlight
ABSTRACT:
SUBMITTER: Zhang F
PROVIDER: S-EPMC6317738 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20180801 6402
Excess dietary lipid uptake causes obesity, a major global health problem. Enterocyte-absorbed lipids are packaged into chylomicrons, which enter the bloodstream through intestinal lymphatic vessels called lacteals. Here, we show that preventing lacteal chylomicron uptake by inducible endothelial genetic deletion of <i>Neuropilin1</i> (<i>Nrp1</i>) and <i>Vascular endothelial growth factor receptor 1</i> (<i>Vegfr1</i>; also known as <i>Flt1</i>) renders mice resistant to diet-induced obesity. A ...[more]