Ontology highlight
ABSTRACT:
SUBMITTER: Park JS
PROVIDER: S-EPMC7562726 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Park Jin-Sung JS Lee Woon-Kyu WK Kim Hyeon Soo HS Seo Ji A JA Kim Dong-Hoon DH Han Hee Chul HC Min Bon-Hong BH
Scientific reports 20201015 1
Obesity is a significant risk factor for various metabolic diseases and is closely related to non-alcoholic fatty liver disease (NAFLD) characterized by inflammation and oxidative stress. Clusterin is a multi-functional protein that is up-regulated in the pathogenesis of various metabolic diseases, including obesity and NAFLD. Our previous studies indicated that hepatocyte-specific overexpression of clusterin alleviates methionine choline-deficient (MCD) diet-induced non-alcoholic steatohepatiti ...[more]