Sequence-Independent DNA Nanogel as a Potential Drug Carrier.
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ABSTRACT:
SUBMITTER: Zhang W
PROVIDER: S-EPMC6317892 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Publications
Sequence-Independent DNA Nanogel as a Potential Drug Carrier.
Zhang Weiqi W Tung Ching-Hsuan CH
Macromolecular rapid communications 20170912 20
DNA nanostructures largely rely on pairing DNA bases; thus, sequence designing is required. Here, this study demonstrates a sequence-independent strategy to fabricate DNA nanogel (NG) inspired by cisplatin, a chemotherapeutic drug that acts as a DNA crosslinker. A simple heating and cooling of the genomic DNA extracts and cisplatin produces DNA NG with a size controlled by the heating time. Furthermore, the drug-loaded NG is formulated by spontaneously mixing DNA segments, cisplatin, and doxorub ...[more]
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