Ontology highlight
ABSTRACT:
SUBMITTER: Yu M
PROVIDER: S-EPMC6318069 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Oral diseases 20180723 3
Tooth agenesis (TA) is one of the most common developmental anomalies that affects the number of teeth. An extensive analysis of publicly accessible databases revealed 15 causative genes responsible for nonsyndromic TA, along with their signaling pathways in Wnt/β-catenin, TGF-β/BMP, and Eda/Edar/NF-κB. However, genotype-phenotype correlation analysis showed that most of the causal genes are also responsible for syndromic TA or other conditions. In a total of 198 different mutations of the 15 ge ...[more]