Chromosomal Conformations and Epigenomic Regulation in Schizophrenia.
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ABSTRACT:
SUBMITTER: Rajarajan P
PROVIDER: S-EPMC6318347 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Publications
Chromosomal Conformations and Epigenomic Regulation in Schizophrenia.
Rajarajan Prashanth P Jiang Yan Y Kassim Bibi S BS Akbarian Schahram S
Progress in molecular biology and translational science 20180330
Chromosomal conformations, including promoter-enhancer loops, provide a critical regulatory layer for the transcriptional machinery. Therefore, schizophrenia, a common psychiatric disorder associated with broad changes in neuronal gene expression in prefrontal cortex and other brain regions implicated in psychosis, could be associated with alterations in higher-order chromatin. Here, we review early studies on spatial genome organization in the schizophrenia postmortem brain and discuss how inte ...[more]
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