Ontology highlight
ABSTRACT:
SUBMITTER: Hoffman GE
PROVIDER: S-EPMC6760149 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Hoffman Gabriel E GE Bendl Jaroslav J Voloudakis Georgios G Montgomery Kelsey S KS Sloofman Laura L Wang Ying-Chih YC Shah Hardik R HR Hauberg Mads E ME Johnson Jessica S JS Girdhar Kiran K Song Lingyun L Fullard John F JF Kramer Robin R Hahn Chang-Gyu CG Gur Raquel R Marenco Stefano S Lipska Barbara K BK Lewis David A DA Haroutunian Vahram V Hemby Scott S Sullivan Patrick P Akbarian Schahram S Chess Andrew A Buxbaum Joseph D JD Crawford Greg E GE Domenici Enrico E Devlin Bernie B Sieberts Solveig K SK Peters Mette A MA Roussos Panos P
Scientific data 20190924 1
Schizophrenia and bipolar disorder are serious mental illnesses that affect more than 2% of adults. While large-scale genetics studies have identified genomic regions associated with disease risk, less is known about the molecular mechanisms by which risk alleles with small effects lead to schizophrenia and bipolar disorder. In order to fill this gap between genetics and disease phenotype, we have undertaken a multi-cohort genomics study of postmortem brains from controls, individuals with schiz ...[more]