Ontology highlight
ABSTRACT:
SUBMITTER: Canver MC
PROVIDER: S-EPMC6319324 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Canver Matthew C MC Joung J Keith JK Pinello Luca L
The CRISPR journal 20180401 2
The CRISPR-CRISPR-associated (Cas) nuclease system offers the ability to perform unprecedented functional genetic experiments and the promise of therapy for a variety of genetic disorders. The understanding of factors contributing to CRISPR targeting efficacy and specificity continues to evolve. As CRISPR systems rely on Watson-Crick base pairing to ultimately mediate genomic cleavage, it logically follows that genetic variation would affect CRISPR targeting by increasing or decreasing sequence ...[more]