Ontology highlight
ABSTRACT:
SUBMITTER: Grizotte-Lake M
PROVIDER: S-EPMC6319961 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Grizotte-Lake Mayara M Zhong Guo G Duncan Kellyanne K Kirkwood Jay J Iyer Namrata N Smolenski Irina I Isoherranen Nina N Vaishnava Shipra S
Immunity 20181201 6
Retinoic acid (RA), a vitamin A metabolite, regulates transcriptional programs that drive protective or pathogenic immune responses in the intestine, in a manner dependent on RA concentration. Vitamin A is obtained from diet and is metabolized by intestinal epithelial cells (IECs), which operate in intimate association with microbes and immune cells. Here we found that commensal bacteria belonging to class Clostridia modulate RA concentration in the gut by suppressing the expression of retinol d ...[more]