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Methyl glycosides via Fischer glycosylation: translation from batch microwave to continuous flow processing.

ABSTRACT:

Abstract

A continuous flow procedure for the synthesis of methyl glycosides (Fischer glycosylation) of various monosaccharides using a heterogenous catalyst has been developed. In-depth analysis of the isomeric composition was undertaken and high consistency with corresponding results observed under microwave heating was obtained. Even in cases where addition of water was needed to achieve homogeneity-a prerequisite for the flow experiments-no detrimental effect on the conversion was found. The scalability was demonstrated on a model case (mannose) and as part of the target-oriented synthesis of d-glycero-d-manno heptose, both performed on multigram scale.

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SUBMITTER: Aronow J

PROVIDER: S-EPMC6320746 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Methyl glycosides via Fischer glycosylation: translation from batch microwave to continuous flow processing.

Aronow Jonas J Stanetty Christian C Baxendale Ian R IR Mihovilovic Marko D MD

Monatshefte fur chemie 20181117 1

<h4>Abstract</h4>A continuous flow procedure for the synthesis of methyl glycosides (Fischer glycosylation) of various monosaccharides using a heterogenous catalyst has been developed. In-depth analysis of the isomeric composition was undertaken and high consistency with corresponding results observed under microwave heating was obtained. Even in cases where addition of water was needed to achieve homogeneity-a prerequisite for the flow experiments-no detrimental effect on the conversion was fou ...[more]

PMID: 30662091

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