Ontology highlight
ABSTRACT:
SUBMITTER: Shin SY
PROVIDER: S-EPMC6320900 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Shin Soon Young SY Lee Youngshim Y Kim Beom Soo BS Lee Junho J Ahn Seunghyun S Koh Dongsoo D Lim Yoongho Y Lee Young Han YH
International journal of molecular sciences 20181217 12
Members of the aurora kinase family are Ser/Thr kinases involved in regulating mitosis. Multiple promising clinical trials to target aurora kinases are in development. To discover flavones showing growth inhibitory effects on cancer cells, 36 flavone derivatives were prepared, and their cytotoxicity was measured using a long-term clonogenic survival assay. Their half-maximal growth inhibitory effects against HCT116 human colon cancer cells were observed at the sub-micromolar level. Pharmacophore ...[more]