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Novel Terpenoids with Potent Cytotoxic Activities from Resina Commiphora.

ABSTRACT: A novel sesquiterpene dimer, spirocommiphorfuran A (1); two new cadinane sesquiterpenoids, commiphorenes A (2) and B (3); along with three known terpenoids (4?6), were isolated from Resina Commiphora. The structures of these new compounds were characterized by NMR, HRESIMS, quantum chemical computation, and X-ray diffraction analysis. Compound 1 features a 7-oxabicyclo[2.2.1]heptane-2-ene core, representing the first example of germacrane-type sesquiterpene dimer fused via a spiro ring system. Compound 2 is a novel sesquiterpene with a completely new carbon skeleton, which is characteristic of an additional carbon attaching to the cadinane backbone via a carbon?carbon bond. Additionally, compounds 2 and 4 exert acceptable cytotoxicity toward normal cells and high selectivity in cancer cells, especially in HepG2 cells.

SUBMITTER: Hu BY

PROVIDER: S-EPMC6321302 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature

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Novel Terpenoids with Potent Cytotoxic Activities from Resina Commiphora.

Hu Bin-Yuan BY Qin Da-Peng DP Wang Shao-Xiang SX Qi Jing-Jing JJ Cheng Yong-Xian YX

Molecules (Basel, Switzerland) 20181207 12

A novel sesquiterpene dimer, spirocommiphorfuran A (1); two new cadinane sesquiterpenoids, commiphorenes A (2) and B (3); along with three known terpenoids (4⁻6), were isolated from Resina Commiphora. The structures of these new compounds were characterized by NMR, HRESIMS, quantum chemical computation, and X-ray diffraction analysis. Compound 1 features a 7-oxabicyclo[2.2.1]heptane-2-ene core, representing the first example of germacrane-t ...[more]

PMID: 30544580

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