Involvement of Gastrin-Releasing Peptide Receptor in the Regulation of Adipocyte Differentiation in 3T3-L1 Cells.
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SUBMITTER: Kim MK
PROVIDER: S-EPMC6321486 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
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Involvement of Gastrin-Releasing Peptide Receptor in the Regulation of Adipocyte Differentiation in 3T3-L1 Cells.
Kim Mi-Kyoung MK Park Hyun-Joo HJ Kim Yeon Y Bae Soo-Kyung SK Kim Hyung Joon HJ Bae Moon-Kyoung MK
International journal of molecular sciences 20181210 12
Gastrin-releasing peptide (GRP), a member of bombesin-like peptides, and its receptor (GRP-R) play an important role in various physiological and pathological conditions. In this work, we investigated the role of GRP-R on adipogenesis in 3T3-L1 adipocytes. The expression of GRP-R was significantly increased during the adipocyte differentiation of 3T3-L1 cells. The inhibition of GRP-R by the antagonist RC-3095 affected adipogenesis in 3T3-L1 cells, which reduced lipid accumulation and regulated t ...[more]
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